Photo Credit: Alena Butusava
Bronchial biopsy (BB) appears more accurate than score of T2 inflammation (T2 score) in predicting response to biological therapy for severe uncontrolled asthma (SUA), according to study results published in chest. For the study, Cristina Gómez Bellvert, MDand colleagues evaluated BB according to a previously validated pathologic score (PS) and compared BB with a T2 score that included blood eosinophil count and FeNO in predicting biological response among patients with SUA. A total of 78 patients were enrolled and treated. PS was the only variable independently associated with biological response, with patients deemed “super responders” showing significantly higher PSs. Poor response to biological therapy was associated with low tissue eosinophila (<10 eosinophils/field). “Tissue eosinophilia is the main driver of this predictive capacity, but there are other items in the PS related to bronchial remodeling that might be contributing to the identification of response to biological therapy,” Dr. Gómez Bellvert and colleagues wrote.
