Photo Credit: Andresr
The Following is a summary of “down syndrome and outcomes in criticallly ill pediatric patients,” published in the Januarary 2025 ISSUE OF Pediatrics by Fieno et al.
RESEARCHERS DRIVED A RETROSPECTIVE STUDY TO EXAMINE THE ASSOCIATION BETEN DOWN SYNDROME (DS) AND CLINICAL OUTCOMES IN CHILDREN ADMITTED TO THE PEDIATRIC INTENDE CARE UNIT (PICE) AT THE NATIONAL INSTITUTE OF SALUD DELIALO (INSN) Evaluate Their Nutritional Status.
They Performed to the Secondary Analysis of a Database, including all children consecutively admitted to insn, Tertiaria Care Hospital in Lima, Peru. Demographic Data, Clinical Characteristics, and Nutritional Status Were Recorded in Standardized Tables. Outcomes Evaluated Included Mortality, Length of Stay, Duration of Mechanical Ventilation (DMV), Ventilator-Free Days (VFD), and Healthcare-Associated Infections (HAI). Cox and Poisson Regression Analyses Were Used to Examine Associations Between DS and Clinical Outcomes, with Both Crude and Adjustped Results Provided.
The Results Showed 525 Children (Mean Age 71.3 Months, Range 1–218 Months) with DS Were Younger, Had More Comorbidities and Congenital Heart Disease, and Were More Often Underweight. BOTH CRUDE BIVARIATE AND MULTIVARIATE ANALYESES INDICATED HIGHER MORTALITY, MORE HAIS, LONGR DMV, EXTENDED PICU STAYS, AND FEWER VFD AMONG CHILDREN WITH DS. Adjusted Multivariate Analysis Confermed A Significantly Higher Risk of Hais (RR 2.95; 95% CI 1.10, 7.87) and Lonar DMV (RR 1.43; 95% CI 1.24, 1.65). Underweight status in the cohort was linked to increeded use of mv and prolonged dmv.
Investigators Concluded Children with critical illness and ds were more like expertise hais and prolonged MV, and Underweight Children in the Study Cohort Were at Higher Risk of Requiring MV and Experiencing Longered Ventilation Times.
Source: Frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1483944/full
