Photo Credit: Yogenyogeny
The Following is a Summary of “Agreement Between Color, Fluorescein Angiography, and Sd-Cet in the Detection of Macular Fibrosis In Neovascular AMD,” Published in the Januarary 2025 ISUE OF OF Ophthalmology by CSincsik et al.
Color Imaging is the Standard Reference for Detecting Macular Fibrosis In Neovascular Age-Relass Macular Degeneration, With Fluorescein Angiography (FA) and Spectral Domain Optical Coarence Tomography (SD-CT) Also Used, Thought in the formal aggregation studies exist.
Researchers Drive the Retrospective Study to Evaluate The Agreed Between Fibrosis on Color Imaging, FA, and SD-CET-DEETED HYPERREFLETIVE MATERIAL (HRM) and Clinical Relevance.
They Analyzed Multimodal Fundus images (Color, FA, and SD-CT) of 130 Eyes with neovascular Age-Related Macular Degeneration from the Edna Study, 18 Months Post-Incular Endothelial Growth Factor (Anti-Vegf) Treatment. Fibrosis and hrm were rigeded, with hrm locations classified as subretinal (SR) or subretinal Pigment epithelial (SPE). The Kappa Statistics Assessed the Agreement Between Detection Methods, and Regression Analysis Evaluated Clinical Relevance Using Best Corrected Visual Accuity (BCVA) As The Outcome Variable.
The Results Showed the Kappa Value for Fa Was 0.56, While for HRM On SD-CT, It Was 0.40, Using Color As the Reference. Regression analysis Against BCVA Revealed low r2 VALUES FOR ALL TESTS (R2 <0.09). However, in the HRM-CET MODEL, Using no HRM as the Reference and Location/Dimensions As Covariates, R2 Improved to 0.301. Letter Loss Was 21.1 (P <0.0001) For SR and 8.1 (P = 0.045) for SPE. WHEN HRM ON SD-CET SERVED AS THE REFERENCE, SENSITIVITY FOR COLOR OR FA WAS 87.5% FOR SR BUT DROPPED TO 15.2% -33.3% FOR SUBRETINAL PIGMENT EPITHELIAL (SUB-RPE).
Investigators Concluded That Well-Defined HDM Detected by SD-CET DURING THE MAINTENANANCE PHASE OF ANTI-VEGF THERAPY ACCOUNTED FOR BCVA, SUGGESTING SD-CET BE A superior Standard for Detecting Fibrosis Compred to other methods.
