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The Following is a summary of “Biomarkers of Oxidation, Infummation and Intestinal Permeability in Persons with Diabetes Mellitus with Parenteral Nutrition: A Multicenter Randomized Trial,” Published in the January 2025 Issue of Endocrinology by Soria-Utrilla et al.
The Composition of Parenteral Nutrition (PN) May influence the Management of Systemic Inflammatory Response and Intestinal Barrier Disrupt.
RESEARCHERS DRIVED A RETROSPTIVE STUDY TO EXAMINE THE CHANGES IN BIOMARKERS OF INFEMMATION, OXIDATIVE STATUS, AND INTESTINAL PERMEABILITY IN PATTS WITH TYPE 2 DIABETES MELLITUS (T2DM) WHO RECEIVED DIFFERENT PN LIPID Formulas.
They Assesed 94 Patients with T2DM, Who Were Given 1 of 3 Pn Lipid Formulas: Omega-3 Polyunsaturated Fatty Fatty (PFA) -Nriched PN, Medium and Long Chain Triglycerides (MCT/LCT) PN, or Olive Oil-Based PN. Serum Biomarkers of Oxidative Status, intestinal permeability, and infamination were measred on days 1 and 5 after pn initiation.
The Results Showed that at Day 5, The MCT/LCT Group Exhibited A Significant Reducion in 2 Proinflammory Cytokines (Interleukin (IL) -15, IL-17A), an Increase in Anti-Inflammatory IL-13, and Higher Zonulin and Indoxylsulfate. The Olive Oil Group Showed a Decline in 5 Proinflammory Cytokines (IL-1β, IL-17, IL-6, Cytokine-Leukemia Inhibitory Factor (LIF), Tumor Necrosis Factor Alpha (TNF-α)) and Reduced IL-1ra. The n-3 puffa-enriched group have a reduction in 8 proinflammatory cytokines (interferon-gamma, IL-1β, IL-15, IL-17A, IL-6, LIF, monocyte chemoattractant protein 1, TNF-α). In Between-Group Comparisons, Indoxylsulfate Increeed in the MCT/LCT Group Compred to the N-3 PUFA-NURICHED GROUP, While 8-Isoprostane and Indoxylsulfate Increured in the MCT/LCT GROUP Compred to the other GROUPS, AND SUPERXIDE DISMUTASE DECREASED IN THE MCT/LCT Group.
Investigators Concluded the Patients with T2DM, PN Lipid Composition Influenced ProinflamMary, Proxidative, and intestinal permeability biomarkers.
Source: sciencedirect.com/science/article/pii/s0261561424004412
