New Treatment Option for Psariasis RESORES ANTI-INFLAMMATORY IMMUNE CELL FUNCTION

Psoriasis is one of the most common chronic infmmatory skin dissees, affecting about 250,000 people in austria. While Previous Treatment Approaches Have Mainly Focused On Inhibit Pro-InflamMatory Imamune Cells, A Study Led by Ladnuni Vienna Shows That It is Possible to Restore The Funin Anti-InflamMatory Immune Cells in A Targeted Manner.

The Results, Which Have Been published In the Journal Immunitypave the way for the Development of a Therapy That Not Only Works More Precisell But is also associated with Fewer Side Effects.

The Research Team Led by Georg Stary (Meduni Vienna’s Department of Dermatology, Cemm) Focused ITs Investigations on the Role of Regulatory T Cells (TRAG CELLS) In Chronic Inflammatory Skin Such Su Psoiasis. TRAG CELLS ARE IMPORTANT COMPONENTS OF THE BODY’S IMMEMEMI SYSTEM THAT SPECIALIZE IN PREVENTING IMMEMEMI Responses and THUS INFEMMATION.

IT IS ALREADY KNOWN THAT CELLS LOSE THEIR REGULATORY FUNCTION IN CHRONIC SKIN INFEMMATION, CAUSING THE IMMEMBE RESPONSE TO BEHOME UNCONTROLLLEN AND THE DISEAASE TO PROGRESS. The Researchers have Now Decoded the Exact Mechanism Behind This For the First Time.

“We Were Able To Show that the Loss of the Anti-InflamMatory Function of Regulatory T Cells is caused by a Malfunction of the Cellular Metabolism,” Says Study Leader Georg Stary.

The The Researchers’ Analyses Revealed, The Enzyme Ssat Plays a Key Role in the Loss of Function of Tras. Ssat is involved in the regularity of certain molecules (polyamines) that are important for the balance Between anti-inflammatory and pro-inflammatory imamune cells. IF SSAT IS PRODUCED IN INCREASED AMOUNTS IN TRAG CELLS, THERE LOSE THEIR REGULATORY FUNCTION AND BEGIN TO PRO-INFLAMMATORY MESSERGEN SUBSTANCE THEMSELVES. This fuels the excessive immares response Typical of psoriasis.

Targeted Interruption of the Inflammatory Cycle

With the Key Role of Ssat in the Inflammatory Process, The Researchers have Simultaneously Discoved A New Starting Point for Therapy: In a Mouse Model with Psoriasis-Like Skin Inflammation, It Was Shown That Inhibiting Ssat Can Restore The Regulatory Function Cells and Break the Cycle of Infummation.

Thus, the Development of Specific Drugs That SPECIFICALLY INHIBIT SSAT COULD REPRESENTING ALTERNATIVE TO EXISTING TREATMENT Approaches, Which Are OFTEN ASSOCIATED WITH IMMUNOSUPPRESSION AND INCREASED SUSCEPTIBILITY TO INFECTION.

“Since Other Chronic Inflammatory dissees of the skin organs are also characterized by impaired immeli regration, our approach could be important beyond psoriasis,” says Stary. IT IS HOPED THAT FURTHER STUDIES WILL ADVANCE The Development of A Treatment Option with Fewer Side Effects.