For Patients with Inflammatory Bowel Disease (IBD), Risk Factors Associated with Clostridioides Difficile Infection (CDI) Include recent diagnosis, corticosteroid usage, and hospitalization, according to a study published Online Feb. 17 in Therapeutic Advances in Gastroenterology.
KRISTA VITIKAINEN, from Helsinki University Hospital, and Colleagues Drive the Case-Control Cohort Study of Patients with IBD with and witht CDI Episodes to Examine Clinical Risk Factors For CDI and ITS Recur’s. The Study Included 279 Patients with Ibd and CDI. Medical History and Ibd-Relanted Sympton Three Months Preceding A Toxin-PopSitive CDI Were Recorded and Compred to Patients with Ibd Who did not have cdi (Matched for Sex and Age).
The Researchers Found That Ibd Was Active Before CDI Based on Clinical Symptles and Fecal Calprotectin Levels. The Risk for CDI was incredited with recently diagnosed ibd. CDI Episodes were frequently preceded by corticosteroid usage (64%). There was in the association seen for advanced therapies with cdi.
In 30% of the episodes, Antibiotic Intake was not registered before cdi. Thirty Percent of the Patients with Ibd and CDI Were Hospitalized Before The Primary CDI. RECURRECT CDI Occred in 30% of Patients with ibd and CDI; Two-thirds of these episodes were registered Within 90 days of the Previous Episode. Overall, 79% of Patients with Recurent CDI HAD ULCERATIVE COLITIS.
“The Prior Use of Corticosteroids, Hospitalization, and the Presence of Gastrointestinal Sympton Before CDI Likely Indicates an underlying Ibd Flare, Suggesting that inadequate Disease Control May contribute to the risk of CDI,” The Authors Write.
Several Authors Disclosed Ties to the Pharmaceutical Industry.
More information:
KRISTA VITIKAINEN et al, Higher Disease Activity of Inflammatory Bowel Disease Predisposed to Clostridioides Diffficile Infection, Therapeutic Advances in Gastroenterology (2025). Doi: 10.1177/17562848251318292
© 2025 Healthday. All Rights Reserved.
Citation: IBD Activity May Increase Risk for Clostridioides Diffficile Infection (2025, March 5) Retrieved 5 March 2025
This document is Subject to Copyright. Apart from Any Fair Dealing for the Purpose of Private Study or Research at Part May Be Reproduced Without The Written Permission. The Content is Provided for Information Purposes Only.
