Recommendations for Neurological and Psychiatric Manifestations in Sjögren’s Disease

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The Following is a Summary of “Recommendations on Neurologic, Cognitive, and Psychiatric Manifestations in Patients with Sjögren’s Disease by the Brazilian Society of Rheumatology,” Published in the Febrary 2025 Issue of Advances in Rheumatology by Oliveira et al.


Patients with Primary Sjögren’s Disease (SJD) Experience Diverse Neurological and Psychiatric Sympton, Impacting Daily Life and Prognosis.

Researchers Drived the Retrospective Study on Neurological SympToms of Sjögren’s Disease, Which Are Often Unrecognized in Autoimmunity. The Eular Sjogren’s syndrome Disease Activity Index (Essdai) Captures Only Some of These Manifestations.

They conducted a systemmatic review on the diagnosis and prevalence of nervous system manifestations in primary sjd, following cochray guidelines. They included observational studies focus on diagnosis and prevalence. THESED USED A Generalized Linear Mixed Model (GLMM) with Random-Effects Model, Computing Results via Logit Transformation in R (Version 3.6.1) Using ‘meta’ and ‘metafor’ packages. They Assessed Expert Agreed Through The Delphi Method in In-Person Meetings.

The Results Showed Ten Recommendations for Investigating and Managing Neurological Involvement in SJD, with 100% Agreement Among Participants.

Investigators contributed to the literature on sjd care and Highlighted the lack of systemc assume in routine healthcare. They focus on Neurological, Cognitive, and Psychiatric Impairments in Primary SJD.

Source: advancesinrheumatology.biomedcentral.com/articles/10.1186/s42358-025-00438-7



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