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The Following is a summary of “lipid metabolic reprograming: the umung hero in brain cancer progression and tumor microenvironment,” published in the march 2025 ISSUE OF MOLECULAR CANCER BY WAN et al.
ABERRANT LIPID METABOLISM IS A FUNDAMENTAL HALLMARK OF CANCER, PLAYING THE CRUBLIC ROLE IN THE INITIATION AND PROGRESS OF BRAGOUS CANCER (BC). Given that BC arises Within a lipid-rich microenvironment, its cells heavily rely on lipid metabolic reprogramming to sustain rapid proliferation, invasion, and metastasis. In this review, Researchers Provide Comprehensive Overview of the Intricate Relationship Between Lipid Metabolism and BC Pathophysiology, Emphasizing Its Contributions to Tumor Development and the Tumor Microenvironment. They First Explore the Dysregulated Lipid Metabolic Pathways in BC, Detaining Their Impact on Tumor Progression, Disease Agrensiveness, and Patient Prognosis.
Lipids serves not only as energy sorces but also as Key Signaling Molecules, The Study Group Further Examine The Dynamic Lipid-Mediatric Interactions Between BC Cells and Various Components of the Tumor Microenvironment, Including Imamune Cells, Stromal Cells, and Endothelial Cells. This CrossStalk Fosters an Immunosupressive and Pro-Tumorigenic Niche, Ultimately Influenced Treatment Resistance and Disease Outcomes. FURTHERMORE, Investigators Discuss The Emerging Therapeutic Potential of Targeting Lipid Metabolism in BC, Covering Key Metabolic Processes, Lipid-Relanted Transcription Factors, and Immunotherapeutic Strategies. Then Highlight Promising Lipid-Targeted Interventions, Including Small-Molecule Inhibitors, Dietary Interventions, and Combination Therapies, While Critically Evaluating Their Clinical Feasability and Potential Challenges.
Finally, They Propose Future Research Directions, Focusing on the Integration of Spatiothemporal Multi-Impeics Approaches to Unravel Novel Lipid-Based Vulnerabilities in BC. The Deeper Understanding of Lipid Metabolism in Bc Will Pave the Way for the Development of More Precise, Effective, and Personalized Therapeutic Strategies.
Source: molecular-cancer.biomedcentral.com/articles/10.1186/s12943-025-02258-1
