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Interleukin 15 (IL-15) Representations A Potential Target for Severe Asthma, According to Study That Examined Whether Specific T Cell Subsets Impact Asthma Sympton Duration. Richard Ramonell, MDand Colleagues Published The Findings In Jci insight. They Found the Significant Association Between Airway CD8+ Effector Memory T Cells Re-Expressing CD45ra and Asthma Duration in Severe Asthma (SA), But Mild to Moderate Asthma (MMA). This Association Was Not Seen for CD8+ CD45ro+ or Tissue-Resident Memory T Cells. Higher Frequencies of IFN-γ+ CD8+ TERS COMPARED WITH IFN-γ+ CD45RO+ T CELLS WEREVED IN SA AIRWAYS. Further, Airway Il15 Expression Was Higher in Sa Compred With MMA, “Prompted by the Transcriptomic Profile of S CD8+ Storms and Proliferative Response to IL-15,” The Researchers Noted. IL15 EXPRESSION IN ASTTHMATIC AIRWAYS NEGATIVELY CORRELADED WITH LUNG FUNCTION. “Our findings add a new dimension to understanding asthma heterogeneity, identifying il-15 as the potential target for treatment,” Dr. Ramonll and Colleagues Wrote.
