Researchers Make Progress Toward Non-Hormonal Treatment for endometriosis

Roughly 200 Million Women Around the World Suffer From Endometriosis, A Condition That Tissue From the Lining of the Uterus To Grow in Places Outside of the Uterus. The Condition can be excellent painful and contributes to infertility.

Endometriosis is As Common as Type 2 Diabetes, Rheumatoid Arthritis and Migoines in the US, Although There is Less Awareness of This Condition. This lack of familiarity with endometriosis among the General Population and Health Care Providers Means this condition is not well understood.

“Endometriosis is an Understudied Disease,” Said Asgerally Fazleabas, Professor and Associate Chair of Research in the Department of Obstetrics, Gynecology and Reproductive Biology in the Michigan State University Medicine. “Unless you go to physician who knows whatometriosis is, it may be misinterpreted as a gastrointestinal problem or infmmatory bowel disease.”

New Findings from A Team That Includes Msu Researchers Points The Way To Developing New Non-Hormonal Therapies Which Could Be a Game Changer for Endometriosis Patients, Some of Whom Wait Seven to 10 Years for Diagnosis. This Research was Funded by the National Institutes of Health and the Endometriosis Foundation of America.

Endometriosis Starts Early for Most Patients

“Endometriosis Begins for Most Girls in Adolescence – Wen Thes Start Having Their Periods, Sometimes As Early As Eight Years Old,” Fazleabas Said. “Many of These Girls Have Periods Complicated with Very Severe Pelvic Pain That Lasts Throughout Their Teenage Years. It Affects So Much of Their Normal. Many of Them Cannot Even Go to School when the pain is Intense, and It Also Significant Aphfects Their Social Life.

“The Only Way to Conclusly Diagnosis Endometriosis is to have a laparoscopy and most physicians are reluctant to performer procedure on a Young Girl,” Said Fazleabas, Who is also director of the center for womens’s health research and co-director of the reproductive and developimental Sciences Training Program at MSU.

For Older Women, Gynecological Complications Like fibroids or adenomyosis can make an endometriosis diagnosis more diffult.

Study Provides Baseline for Novel Non-Hormonal Treatments

This Study by Fazleabas and His Co-Researchers Provides Baseline for Understending The Signals, Or Cross Talk, Between The Immune System’s Macrophage Cells and Cells In Endometriosis Lesions. Their Findings have been published in Iscian and could help lead to better non-hormonal treatments for endometriosis.

“What We Were Able To Show Is That the Epithelium – Layer of Cells Within an endometriosis lemon –is Aple to Selective Communicate with the macrophages and alter their function with the imammune system,” Fazelabas Explained. “In General, Macrophages AREImmune Cells Othose Role is to Help Protect the Body BY Detecting and Removing Harmful Substances, Controlling Inflammation and Aiding In Tissue Repair.

“But macrophages can take on different forms,” ​​he added. “Other Researchers have Shown That Macrophages Found Within the Lessions TEND TO BE PRO-TISSUE REPAIR. So, Rather Than Clearing the Tissue, They are contributing to the development of endometrics.

“What We’ve Shown in This Paper Is That The Epithelial Cells Can Communicate with the Macrophages,” Concludes FazaBas. “Our hypothesis is that their cross talk potentially provides an enrollment that’s conduct to the development of the disseum.”

This baseline for understanding cellullar cross talk provides the foundation for a function research that could lead to better therapies for the treatment of endometriosis.