Delay of more than 42 days for brain cancer surgery raises death risk for certain subtypes, study finds

Patients with right subtypes of brain cancer may face to higher risk of death from the cancer if they were wait more than 42 days after diagnosis to have surgery, according to newly published research from the university of oklahoma.

The Research Team Was Surprised That the Subtypes of Breast Cancer Most Affected By Delayed Surgery Were Those with the Best Prognosis: Hormone Recepting Breast Cancers, Meaning The Cancer Uses Strogen or Progesterone To Grow, And Her2-Negative Cancers, Which of Not Have Have Have High Levels of the Her2 Protein That Is Associated with More Aggressive Cancer Growth.

These Subtypes, Those Initial Treatment is Surgery, Tend to Grow More Slowly. But when surgery was delayed in the Study, Patients’ Risk of Death from the Cancer Increased Exponyntially.

The Risk began to Increase at 42 Days Without Surgery, and by 60 days, the Patient’s Risk of Death was 21% Times Higher. By 90 days, The Risk Was 79% Times Higher, and by 120 days, The Risk Was 183% Higher.

In Contrast, hormone receptor-black and “triple negative” subtypes, Which are aggressive and invasive, Changed Very Little During Treatment Delays.

“This is an important finding because 42 days can go by very Quickly, but it’s also Connerning Because recent studies Show That Both the Frequency and Length of Delay Are Increasing, “Said Lead Author Takemi Tanaka, Ph.D., Professor of Pathology in the or College of Medicine. The Study is published In the Journal Breast Cancer Research.

Many Factors Can Cause Surgery Delays, Tanaka Said. The Diagnosis and Preoperative Process Can Take Several Days, and Patients May Have Work or Family Obligations That Further Delay the Surgery Date. Some May Want a Second Opinion, and Other Women of Childbearing Age May Want To Pursue Egg Preservation (if they will betherapy after surgery), So They Can Have A Baby in the Future. All Are Important Considerations, She Said.

“In 2022, the Commission on Cancer Recommended That Most Women with Breast Cancer Undergo Surgery Within 60 Days. That was a major victory, but some women May need to have surgery sooner than 60 days, “Tanaka Said.” And while we go people to Understand the Risk of Delaying Treatment, We Also Want Them to Time to Pursue Egg Preservation Or Get A Second Opinion. “

Researchers have Several Hypotheses As to Why Treatment Delay Increases The Risk of Death in These Private Subtypes of Breast Cancer. One Is That, BECAUSE THEY ARE SLOWER-BROWING, THEY HAVE MORE ROOM FOR CHANGE, UNLIKE CANCERS THAT ARE ALREADY INVASIVE. Another hypothesis focuses on the biopsy, which appears to cause an infummatory response that may fuel tumor Growth. In A Publication Last Year, Tanaka Showed That Nonsteroidal Anti-InflamMatory Drugs (NSAIDS) Can Superpress Infummation in A Mouse Model of Breast Cancer After Biopsy.

Research in this area has been onging. In 2020, Canadian Researchers Analyzed 34 Studies on 17 Types of Cancer and Found That Treatment Delay Was A Critical Contributing Factor to Risk of Several Types of Solid Tumors, Notably A 6% To 8% Increased Risk for Each Four-Week Delay In Treatment.

However, Tanaka’s Research is Believed to Be the First To Study When All Breast Cancer Patients Have an Equal Risk of Death, or if the Risk Differs Among Subtypes. Importantly, She also Measred Whether Patients Died Specifically From Their Breast Cancer. Other Studies have loked at overall survival, which includes causes of death other Than cancer.

Tanaka’s New Study Also Both Conferms and Builds on Her Previous Study Showing that pits with the hormone receptor-positive Breast Cancer Who Didn’t Receive Surgery Until 61 to 90 days after diagnosis 18% more likely to have tumor size upstaged (Changed to a more Serious Stage) First 30 days after diagnosis. There was 47% Likeliod of Tumor Upstaging for Patients Who Underwent Surgery Beyond 90 Days.

In Addition, Her Previous Study Used data from the National Cancer Database, the based hospital database that collects cancer data from across the nation. For the current study, she used data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (Seer) -Medicare-Linked Database, Which is More Representative of the Population, She Said.

FURTHER STUDY IS WARRANTED, TANAKA SAID, AND STU SOON LAUNCH A CLINICAL TRIAL ON THE OR HEALTH SCIENCES CAMPUS IN OKLAHOMA City TO SEEK MORE ANSWERS ABOUT How Treatment Delay to an Increased Risk Of Death.