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The Following is a summary of “The Novel Molecular Regulatory Network in Bone Marrow Mesenchymal Stem Cells for Age-Related osteoporosis,” Published in the March 2025 Issue of Clinical endocrinology by Gao et al.
Researchers Drive the Retrospective Study to Analyze Mirna-MRNA Regulatory Networks Influencer Bone Marrow Mesenchymal Stem Cell (BMSCs) Senescence in Age-Relanted Osteoporosis (Aro), Aiming to Determine Molecular Markers and Therapeutic Targets.
They Analyzed 5 MRNA DataSets to Identify Differentially Expressed Genes Linked to Senescence and OsteoporSis, 7 Hub Genes Were Encrysted in the Pi3k-Akt Signaling Pathway, with 22 hub mirnas identified as potential regulatory. The Primary BMSCS Were Harvested and Cultured from 7 Younger Non-osteoporotic Individuals and 6 Older Adults with osteoporosis. Quantitative Real-Time Polymerase Chain Reaction (QRT-PCR) Was Employed to Validate the Expression Levels of the Hub Genes and Mirnas.
The Results Showed That Expression Analysis Revealed Significant Differentes in Integrin Subunit Beta 3 (ITGB3), Receiver Tyrosine Kinase Ligand (Kitlg), and Platelet-Derived Growth Factor (PDGFB), Along with the Associated Regulatory Mirnas, Between The 2 BMSC groups.
Investigators Concluded that mirna-mirna regulatory network might have mediated rim through the pi3k-akt signaling pathway in bmscs.
