Low LDL Cholesterol Levels Linked to Reduced Risk of Dementia

People with Low Levels of Low-Density Lipoprotein Cholesterol (LDL-C) In Their Blood have the Lower Risk of Dementia, Including Lower Risk of Alzheimer’s Disease-Related Dementia, shows A Study Published online Journal of Neurology Neurosurgery & Psychiatry.

Use of Statins Conveyed an additional Protective Effect for People with Low Low LDL-C, Specifically Those with Blood Levels Less Than 1.8 mmol/L (<70 mg/dL), Reducing Their Risk of Dementia Even Further.

However, LDL-C to Very Low Levels Below 0.8 mmol/L (<30mg/dl) Did not reduce dementia risk.

The Benefits of Low LDL-C Levels to Protect Against Cardiovascular Events is Well Recognized, But the Relationship Between LDL-C Levels and Dementia Has Been Clear, Particularly The Cut-Off For LDL-C Below Wich There is in Further Benefit for Cognitive Decline.

To Address this, The Authors Accessed Data ColleCted by 11 University Hospital Hospitals on Adult Outpatients with No Previous Diagnosis of Dementia FolloWed for At Least 180 Days After LDL-C Testing. THES IDENTIFIED 192,213 PEOPLE WITH LDL-C LEVES LESS THAN 1.8 mmol/L (<70mg/dl) and 379.006 PATINS WITH LDL-C LEVES MORH 3.4 MMOL/L (> 130mg/DL), AND MATCHED INDOCH GROUP INTO INTO 108,980 MATCHED pairs.

Analysis of Subsequent Diagnosis of Dementia Showed That LDL-C Levels Below 1.8 mmol/L (<70mg/dl) Were Associated with 26% Reduction in the Risk of All-Cause Dementia and A 28% Reduction in the Risk of Alzheimer's Disease-Relanted Dementia, Compreded with LDL-C Levels Above 3.4 mmol/L (> 130mg/dL).

The Protective Effect Againt Cognitive Decline Lesened at Lower Lower-C Levels and Eventually Disappeared Entirely. At LDL-C Levels Below 1.4 mmol/L (<<55mg/dl), there was an 18% risk reduction for both all-cause and alzheimer's disregarded dementia compared with ldl-c Levels above 3.4 mmol/l (> 130mg/dl), and when ldl-c Levels Fell Below 0.8 mmol/L (<30mg/dl) The Risk Reductions Disappeared.

Statin Use Conference Additional Protection Against Dementia in the Presence of Low LDL-C Levels. Among People with LDL-C Levels Below 1.8 mmol/L (<70mg/dL), Statin Use Was Associated with to 13% Reduction in All-Cause Risk and 12% Decrease in Risk of Alzheimer's Disease-Related Dementia Compred with Non-USers.

This is an observational Study, and As Such, in the Firm Conclusions can be drawn about cause and effect. The Authors Also Acknowledge That the Study Has Some Limitations, Including the Potential For UNMEASURED FACUSE OF ITS RETROSPECTIVE DESIGN, POSSIBLE UNDREPORTING OF DEMENTION CASES DUE TO DIAGNOSTIC ACCURACY BETWEEN HOSPLES, AND THE FOCUS ON BASISLINE LDL-C LEVES WHEN LIPID PROFILES COULD CHANGE OVER TIME.

Nevertheless, The Authors Conclude, “Low LDL-C Levels (<<70 mg/dl (<<1.8 mmol/L)) Are Significantly Associated with A Reduced Risk of Dementia, Including Alzheimer's Disease-Related Dementia, With Statin Therapy Processional Protective Effects."

They Add, “These Findings Underscore The Crucial Roller of Managing LDL-C In Lowering Dementia Risk.”