Two scientists will share a Breakthrough Prize in Life Sciences for research that has revolutionized our understanding of multiple sclerosis.
“It’s obviously an honor,” Ascherio told Live Science of the recognition. He added that he’s looking forward to joining the “interdisciplinary forum” of past winners of the prize, who hail from many scientific backgrounds and help decide future winners of the award.
This year’s Breakthrough Prize winners will receive their awards at a ceremony in Los Angeles on April 5.
Related: In a 1st, trial finds vitamin D supplements may slow multiple sclerosis. But questions remain.
The Breakthrough Prizes multiple sclerosis (MS).
In MS, the immune system attacks fatty tissue that surrounds nerve fibers in the brain and spinal cord. Called myelin, this fatty substance helps neurons send signals efficiently. The destruction of myelin undermines neurons’ ability to communicate with one another while also triggering inflammation and scarring in the nervous system.
This leads to symptoms of numbness, weakness, pain, dizziness, slurred speech, coordination problems, and blurred or double vision. Depending on the subtype of MS, a person’s symptoms may come and go or steadily worsen over time; some people’s disease switches from the former relapsing-remitting pattern to the latter, progressive form of the disease.
Hauser, who directs UCSF’s Weill Institute for Neurosciences, helped identify which immune cells actually drive MS.
It was once thought that T cells
Research findings in the 1970s that supported this idea
Hauser’s research filled in the missing piece of the puzzle: Another type of immune cell, called a B cell, is also key in MS. Although he and his colleagues faced resistance to their theory, they eventually got clearance to test a B-cell-targeting drug in MS patients, and it worked. That pivotal study paved the way for B-cell-depleting therapies for MS, such as ocrelizumab
At the very start of his research, “it would have been impossible to imagine that 35 years later B cells would rest, arguably, at the epicenter of MS immunology,” Hauser wrote in a 2015 essay
Related: $3 million Breakthrough Prize awarded to developers of Ozempic-style drugs
Hauser will share his Breakthrough Prize with Ascherio, a professor of epidemiology and nutrition at Harvard University. Ascherio is being recognized for “revealing that Epstein-Barr virus infection is the leading risk for multiple sclerosis.”
Epstein-Barr virus (EBV) causes the common disease infectious mononucleosis, better known as “mono”; over 95% of people catch the EBV virus individual’s risk of MS increases 32-fold .
No other risk factors or viral infections are tied to such a stark increase in the risk for the disease. And absolutely no MS cases were seen among people in the study who hadn’t caught EBV.
“The fact that the virus is so common makes it difficult to prove,” Ascherio said. Difficult, but not impossible — Ascherio mentioned polio as a similar example. The annual rate of symptomatic polio infections in the U.S. peaked in 1952, reaching nearly 58,000 reported cases 21,000 caused paralysis
“So it’s quite common for a virus to be nearly ubiquitous — infect everyone — but cause severe disease, in particular neurological diseases, in only a small minority,” Ascherio told Live Science.
Since the publication of Ascherio’s 20-year study, “there’s been a huge shift” in the field, he said. “Now, EBV has been accepted as a central player and the leading cause of MS.”
However, it’s not yet known how EBV infection ultimately leads to MS. It’s important to note that EBV is a herpesvirus, which means it can lurk in the body, go dormant and reactivate later on. For his part, Ascherio thinks EBV reactivation in the brain is likely important for the development of MS. Figuring out how that mechanism works could help explain why, out of the many people who catch EBV, only a small percentage end up with MS.
But even if that mechanism is unclear, knowing EBV is a key driver of MS points to possible solutions, Ascherio said. For instance, various groups are working on vaccines to prevent EBV infection, with the hope of snuffing out MS down the line.
And in theory, you could come up with something like the shingles vaccine which works by preventing reactivation of the virus that causes chickenpox; perhaps a similar shot could prevent EBV reactivation in the body, Ascherio suggested.
This article is for informational purposes only and is not meant to offer medical advice.
