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The Following is a summary of “bimodal solutions in peritoneal dialysis: what can we expect from different glucose volumes added to the icodextrin bag? Data from simulation procedure,” published in the april 2025 Issue of Journal of Nephrology by Davy et al.
RESEARCHERS DRIVED A RETROSPTIVE STUDY TO ADDRESS Ultrafillation (UF) INSOFFICIENCY IN PERITONEAL DIALYSIS (PD) Using Bimodal Solutions That Combined Crystalloid and Colloid To Enhance Fluid Removal.
They Prepared 3 Bimodal PD Solutions with 100 ml (Solution 100), 150 ml (Solution 150) and 200 ml (Solution 200) of 30% glucose for intravenous (IV) infusion. Biochemical Analyses and Computer Simulations Based on the 3-Pore Model Assessed at and UF Efficiecy. Data on the Clinical Use of Solution 200 WERE RETROSPELIVELY COLLECTED.
The Results Showed That Adding 30% Glucose to Icodextrin 7.5% CREATED A LOW-SODIUM SOLUTION. After 6-h dwell with solution 200 in a high averag transporter (d/p creatinine 0.7), UF was 943.0 ml and sodium removal were 8.29 g, compared to 650.3 ml and 6.14 g with solution 100. Solution 100 Had the best uf, and sodium efficiency base on glucose absorbed. Of these 4 Patients Used Solution 200 for Least 2 Months Beteen 2018 and 2023. Mean PD Time Before Bimodal PD Was 26 Months (6–38), and Median Time on Bimodal PD Was 15 Months (12–19). In the peritonitis was reported.
Investigators described the simple method to prepare the bimodal solution. They Found That Adding 100 ml of 30% Glucose to 2 L of Icodextrin 7.5% Gave the Best UF and Sodium Efficiency.
Source: Link.Springer.com/article/10.1007/s40620-025-02206-8
