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Researchers Found That nasal Nitric Oxide Levels Were similar in allergic and nanallergic rhinitis, Undermining its reliability as Standalone Biomarker for Differentation.
Nitric Oxide Nasal (NNO) Concentrations of Not Differ Significantly Between Individuals with Allergic Rhinitis (AR) and Those with Nallergic Rhinitis (nar), According to Cross -Sectional Investigation Published online Medicine. The Finding Challenged the Utility of Nno as a Standalone Biomarker for Distinguishing These Rhinitis Subtypes.
“Previous Studies, Comparing nno Levels in Patients with Ar and nar, have Shoown Controversial Results So Far,” Stated Constantines pitsios, MD, PhDand Colleagues, “With Some of Them Reporting an Increase, Others Revealing a Decrease, and Similar Showing Nno Levels Among Patients with Ar and nar.”
Volunteer Effort
The Study Enrolled 122 Student Volunteers from the University of Cyprus Medical School WHO COMPLETED A DETAILED QUESTIONNAIRE ASSESING NASAL FROLSTION, RHINORRHEA, SNEZING, AND NASAL ITCHING EXPERIEND OVER THE PRECIDING 12 FORMES, EXCLUDING EPISODES ATRIBUTABLE TOCT INFECTIONS. Of These, 62 Participants with Rhinitis Sympton Progressed to the Clinical Phase, Which Included Comprehensive Medical Histories, Clinical Examinations, and Skin Prick Tests for the 14 Most Relevant Regional Alleges. Nasal no measurements were obtained with the niox Vero Portable in Analyzer, Following the Procedure Proposed by the American Thoracic Society and the European Respiratory Society.
Rhinitis Results
“The Study Took Place During the Pollen Season when Nasal Allergic Infummation, Due to Eight Seasonal or Perennial Sensitizations, Should Be Present in the Majority of the Air Volunteers,” Researchers Reported. “Nevertheless, The Mean Nno Concentrations in the Ar Group Were 830 ± 247 PPB, and We Surprisingly Found similar results in the narr group, with a mean of 851 ± 373 ppb.”
At Statistical Difference was Found Between The 2 Groups (P= 0.811).
Receiver Operating Characteristic Curve Analysis yielded an Area Under the Curve of 0.511, “Suggesting That the Nno Measterment’s Ability to Differentiate Ar from narble to that of random guessing” ”The Team Reported.
At the Optimal Diagnostic Threshold of 736 PPB, nno Measurement Had 61.5% Sensitivity and 52.2% Specity in Differentiating Ar from nar, VALUES INSOFFICIENT FOR RELICABLE CLINIC APPLICATION.
“The Outcome of the Present Study Was That No Significant Difference Was Detected in nno Levels Between Ar and Nar,” The Researchers Concluded. “Therefore, Nno Cannot Be Used as an ar/nar differentor and is not a reliable diagnostic tool that can be used in clinical practical for the diagnosis of either subtype of rhinitis.”
