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The Following is a summary of “Twice Against Thrice-Weekly Hemodialysis (Tath): A Multicenter Nonrandomized Trial,” Published in the April 2025 Issue of BMC Nephrology by Aoun et al.
The Ideal Frequency for Maintenance Hemodialysis is Still Unchlear. Twice-oeekly sessions remain Common in many regions. The Study Assessed Survival and Potential Risks Over a 2-Year period. RESEARCHERS DRIVED A RETROSPTIVE STUDY TO COMPARE OUTS BETWEEN TWICE-WEEKLY AND THRICE-WEEKLYSIS.
They included adults with ckd stage 5 starting hemodialysis from Jan 2018 to aug 2021 in a prospective, multicenter, nonrandomized trial. PATIES WERE ASSIGNED TO TWICE- OR THERICE-WEEKLY REGIMENS AND MONITED AT 1, 3, 6, 12, and 24 months. The trial ended early after recruiting 25% of the planned sample due to covid-19 and economic issues. They Used Multiple Conception for Missing Baseline Data, Followed by Logistics Regression to Estimite Propensity Scores. The Primary Outcome was 2-yourar Survival Using Cox Regression Adjustped for Propensity Scores and Residual Urine Output. Secondary Outcomes Were Hospitalization, Uncontrolled Hypertension, and Erythropoietin Dose at 2 Years, Analyzed Using regression models with the Same Adjustments. Analyses Followed anin-to-Treat Approach.
The Results Showed 132 Patients on Thrice-Weekly and 71 on Twice-Weekly HemodialYSIS WERE INCLUDED. Mean Age was 67 ± 15 years; Median Egfr was 6 (4.8) ml/min/1.73 m2. AT 1 year, the Twice-Woekly Group Had Higher Residual Urine Output. AT 2 Years, in Significant Differences Were Seen in Survival (HR = 0.84; 95% CI: 0.37, 1.90), Hospitalization (P= 0.515), or unconthrolled hypertension (P= 0.442). The Twice-Weekly Group Showed a Trend Toward Higher Erythropoietin Use (P= 0.08) and Had Higher Serum Potassium and More Antihypertensive Medications.
Investigators found that twice-me hemodialysis Had comparable 2-year survival to Thrice-meta. They Noted it was viable in the first year but refied close monitoring afterward.
Source: bmcnephrol.biomedcentral.com/articles/10.1186/s12882-025-04105-3
