Childhood hepatitis B treatment linked to higher odds of long-term virus control

FUNCTIONAL CURE, DEFINED AS DURABLE HEPATIS B SURFACE ANTIGEN (HBSAG) AND HEPATIS B VIRUS (HBV) DNA TITERS BelOW LIMIT OF DETECTION (LLOD), IS ASSOCIATED WITH BETTER CLINICAL OUTCOMES OF CHRONIC HBV INFERTION AND IS REGAREDED AS THE PREFERED TRETMENT OFMENT OF Novel Therapeutic Agents Against HBV.

Scientists from the College of Medicine of National Taiwan University and National Taiwan University Children’s Identified That the Hepatis B and Antigen (HBEAG) Seroconversion in Childhood, High-Genetic-Barrier Nucleos (T) IDE Analog (S) Therapy Before Hbeag SEROCONVERSION, and the HBSAG TITER <1.000 IU/ML after HBEAG SEROCONVERSION ARE PREDICTORS OF FUNCTIONAL CURE.

The findings Published in the Journal Clinical gastroenterology and hepatology Demonstrate the Merit of the Follow-Up and Treatment of Chronic HBV Infection from Childhood.

Traditionally, The Clinical Course of Chronic HBV Infection in Childhood is Consreded to Be Eventless and Benign. Previous Studies have demonstrated that the Treatment of Chronic HBV-Infected Children with Lamivudine May Increase the Late Complications of Chronic HBV Infection in Adulthood.

THUS, MOST CLINICIANS OFTEN REMERTING CONSERVATIVE OBSERVATION FOR CHILDREN WITH CHRONIC HBV INFECTION. TO TREAT OR NOT TO TREAT CHRONIC HBV-INFECTED CHILDREN With Inflammation Remains UNCLEAR TO DATE.

HBSAGS (below the llod) in combination with undetectable hbv DNA (below the llod) has benimize to minimize the risk of hcc in adults with chronic hbv infection, and the European association for the liver (easl) –ramerican association for the study of live disseeses (AASLD) HBV Conference on Treatment Endpoints Altered the Treatment Goal From Simple Virological Suppression to A “Functional Cure” of HBV.

In a very long-term follow-up cohort from childhood to adulthood in taiwan, the scientists recruised 413 chronic hbv-infested patients who were followed from childhood to adulthood for total of 10.888 person-years in this study.

All of These Subjects Were FolloWed from Hbeag-Positive Status and Finished Their Hbeag-Seroconversion During the Follow-Up Period. Prof Mei-Hwei Chang Launched the Historical Cohort More Than 35 Years Aug.

The exciting date showed that hbeag-seroconversion in childhood (<18 years of age), high-genetic-barrier nucleos

Prof. Jia-Feng Wu from the College of Medicine of National Taiwan University and National Taiwan University Children’s Hospital, And Lead Author of the Study Said, “Our Previous Serial Studies Showed That the Benefit of Hbeag-Seroconversion in Childood is Associated with Basal Chore Promoter Gene Mutations, and predicting a Lower Risk of Hbeag-Negative Hepatis and Liver fibrosis in adulthood. “

“In this Study, We Further Demonstrated the Benefit of Hbeag-Seroconversion in Childhood in PredicT HBV Functional Cure. The Study Further Demonstrated that-Genetic-Barrier Nucleos Benefits The Occurrence of HBV Functional Cure. “

The World Health Organization (Who) has a goal of treating> 80% of patients with chronic viral hepatitis by 2030, and treating or not treating Young Patients with chronic hbv infection (specially children) is a Challenging Issue.

The Who Modified its Recommendations for the Treatment of Chronic HBV in 2024, But the Current Recommendations for Chronic HBV-Infected Children Remain Insufficient.

The Findings of the Current Study Suggest That High-Genetic-Barrier Nucleos (T) IDE Analog (s) Therapy in Childhood Before Hbeag-Seroconversion and Hbeag-Seroconversion In Childhood Benefits In Young Patients (Including Children) With Chronic HBV Infection to Achieve Functional Cure Later in Life.