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Variations in bacterial genera in the small bowel of those spanning normal Weight to Obesity Suggest a correlation Between the gut microbiome and weight.
According to Study Published in The American Journal of Gastroenterology, Variations exist in Specific Bacterial Genera in the Small Bowels of Individuals of Normal Weight, Individuals Who Are Overweight, and Individuals with Obesity. The Findings Suggest A Correlation Beteen Gut Microbiome Composition and Weight.
For this Study, Participants Were Recruredo from the Revealing the Entire Intestinal Microbiota and Its Associations with the Genetic, Immunologic, and Neuroendocrine Ecosystem (Reimagine) Study. Reimagine Comprised Individuals 18 To 80 Years Old Undergoing Standard-Of-Care Upper Endoscopy Without Colon Preparation Who Provided Serum and Duodenal Aspirate Samples.
Researchers Investigated the duodenal microbiomers and serum biomarkers in 214 Study Participants. The Participants Were Stratified by BMI into Three Groups: Normal Weight (n = 105), overweight (n = 67), and obesity (n = 42). The Researchers Examined Small Bowel Microbomes, Employing Specimens Obtained from Esophagogast Produodoscopies, Blood Samples, and Patient Questionnaires.
Small Bowel Microbial Species Associated with Weight
Key Findings Reported by the Authors Include:
- Compred with Normal Weight, The Duodenal Microbiome is Meaningfully Transformed in Overweight and Obesity.
- Specific Microbial Alterations Are Overweight Specific or Obesity Specific; Others are scale or de-scalaction features.
- Bifidobacterium dentium is a de-scale feature in Harmony with recognized antiobesity effects.
- Variations in Lactobacillus gasseri and decreased L Reuteri Are Obesity Specific, But L Acidophilus and L Hominis are de-scale features.
- Specific Lactobacillus Species Are Associated with Type Iia Dyslipidemia, and ALLOPREVOTELLA RAVA is associated with Type IIb and IV Dyslipidemias.
“We Identify Small Bowel Microbial Species Associated with Overweight and Obesity, as well as scale and de-scale features that could potentially be selected asrapeutic targets,” The Researchers Wrote.
IMPORTANCE OF MICROBIOME CHANGES
“Key Finding was that one bacterial population, Lactobacillusin the duodenum exhibited differing and Highly Species-Specific Associations in Subjects Classified as Overweight or Having Obesity, ” Gabriela Leite, PhDLead Author of the Study and Lead Project Scientist for Cedars-Sinai’s Medically Associated Science and Technology (Mast) Program, Said in a press release. “These Microbiome Changes Related to Weight Gain May Be of Private Importance Because Many People Regularly Consume Lactobacillus-Containing Products, Including Dairy-Based Foods, Probiotics, and Certain Vegan Cuisine Such AS Febento Tepeh.”
