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The Following is a summary of “Outcomes of Penetrating Keratoplast Vs Lamellar Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome: A Systematic Review and Meta-Aalysis,” Published in the April 2025 Issue of American Journal of Ophthalmology by Teth et al.
Researchers Conducted the Retrospective Study to Compare Surgical Outcomes Following Penetrating Keratoplast (PK), Descemet Stripping Endothelial Keratoplasts (DSEK), and Descemet Membrane Endothelial Keratoplasts (DMEK) In Individuals with Iridocorneal Endothelial (ICE) syndrome.
They may pre-registered the study in the prosperus database (registration number: CRD42024539444) and retrieved eligible studies from embrais, medline (via pubmed), and the cochrane central register of controlled trials (central) up to april 24, 2024. Clinical Outcomes-Coloft Survival, Best Spectacle-Corrected Visual Account (BSCVA), and Endothelial Cell Density (ECD) –in Individuals with Ice Syndrome After PK, DSEK, Or Dmek. Date Extraction and Synthesis FolloWed The Cochrane Handbook, and the Risk of Bias Was Evaluated by the Risk of Bias in Non-Randomized Studies of Intervention (Robins-I) and Joanna Briggs Institute Critical Appraisal Checklists. Meta-Analyses were executed Using a random-effects model, and heterogeneity was estimated with q-test and i2 Statistics.
The Results Showed That 19 of the 1,963 Screened Studies Were Included in the Meta-Aalysis. Pooled Kaplan-Meier Curves Indicated Better Graft Survival After pk Compred to DSEK in Patients with Ice Syndrome. In Significant Difference (P = 0.92) was observed in bscva improvement between pk (-0.77 (95% ci, -1.45 to -0.09))), DSEK (-0.87 (95% CI, -1.35 to -0.39)), and dmek (-0.85 (95% CI, -1.07 to -0.62)). No Significant Differences in Ecd Were Found Between DSEK AND DMEK AT 6 (P = 0.88) and 12 months (P = 0.33) POSTAPEPETIVELY. Analysis of Individual Patient Data (IPD) Revealed No Significant Difference in Graft Survival Between Those with or Without Glaucoma (-0.04 ± 0.50 without; P= 0.940) or Cataract Surgery (-0.45 ± 0.40 without; P = 0.265).
Investigators Concluded that pk showed supervival survival compared to dsek in paters with ice, but further research was defitive conclusions, while improves in bscva wrei -like across pk, dsek, and glaucoma surgery did not significantly affect graft graft Survival.
