Making large language models accessible for biomedical research

BioChatter: making large language models accessible for biomedical research. Credit: Karen Arnott/EMBL-EBI Large language models (LLMs) have transformed how many of us work, from supporting content creation and coding to improving search engines. However, the lack of transparency, reproducibility, and customization of LLMs remains a challenge that restricts their widespread use in biomedical research. For […]

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Q&A: Identifying an Employment Breach of Contract

Photo Credit: Mironov Konstantin Dr. MedLaw addresses physicians’ questions regarding medical law, providing guidance in this article to a clinician experiencing employment breach of contract. Clinician: I was upfront about my diabetes when interviewing with a pediatrics group. The group hired me, and I relocated. I just needed to pay for a tail for my […]

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Muscular strength and good physical fitness linked to lower risk of death in people with cancer

Credit: Unsplash/CC0 Public Domain Muscular strength and good physical fitness are linked to a significantly lower risk of death from any cause in people with cancer, finds a pooled data analysis of the available evidence, published online in the British Journal of Sports Medicine. Tailored exercise to boost muscle strength and cardiorespiratory fitness in patients […]

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What are plyometric exercises? How all that hopping and jumping builds strength, speed and power

Credit: cottonbro studio from Pexels If you’ve ever seen people at the gym or the park jumping, hopping or hurling weighted balls to the ground, chances are they were doing plyometric exercises. Examples include: box jumpswhere you repeatedly leap quickly on and off a box side skater hopswhere you bound from side to side like […]

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What Is the Optimal Level of Aerobic Training for Weight Loss?

A recent study showed the dose-response effects of aerobic exercise with adiposity measures in adults with overweight or obesity. The findings reinforce current guidelines that 150 minutes a week of moderate intensity or greater aerobic exercise may be needed to achieve clinically important reductions in waist circumference and measures of body fat, according to findings […]

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People who are autistic and transgender/gender diverse have poor health and health care, study finds

Credit: Pixabay/CC0 Public Domain Autistic transgender/gender diverse individuals are more likely to have long-term mental and physical health conditions, including alarmingly high rates of self-harm, new research from the University of Cambridge suggests. Researchers at the Autism Research Center at Cambridge University found that these individuals also report experiencing lower quality health care than both […]

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Basophilia at Diagnosis Associated With Worse Outcomes in Several MPNs

T he significance of basophilia across essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) has not been previously characterized. This led Lisa Yuen, MD, and colleagues to conduct a retrospective study examining a broad cohort of myeloproliferative neoplasms (MPNs) to determine basophilia’s associations with clinical and molecular features and patient outcomes. The researchers […]

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Many Greenlanders face 10 times higher risk of diabetes—exercise may be their only solution

Credit: CC0 Public Domain A significant portion of the Greenlandic Inuit population carries a genetic variant that increases their risk of type 2 diabetes tenfold. Now, researchers from the University of Copenhagen have discovered that the key to addressing this issue lies solely in their muscles. Unfortunately, existing medications are unlikely to help—and in fact […]

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Proinsulin’s Role in Cognitive Function and Brain Cortical Changes

Photo Credit: naiklon1 The following is a summary of “Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment,” published in the January 2025 issue of Endocrinology by Huang et al. Insulin resistance is closely linked to cognitive function, but the causal relationship between the 2 remains unresolved and is a […]

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Fatty muscles increase the risk of serious heart disease regardless of overall body weight, study shows

Researchers used CT scans to analyze each patient’s body composition, measuring the amounts and location of fat and muscle in a section of their torso. SAT = subcutaneous adipose tissue SM = skeletal muscle IMAT = intermuscular adipose tissue. Credit: Vivianty Taqueti / European Heart Journal People with pockets of fat hidden inside their muscles […]

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